Bovine complex I is a complex of forty-five different subunits
نویسندگان
چکیده
The Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, United Kingdom ¶ Current Address GlaxoSmithKline, Stevenage, Hertfordshire SG1 2NY, United Kingdom Running title: Subunit composition of bovine mitochondrial complex I
منابع مشابه
Function of mitochondrial complex-I and -IV in normal human and Parkinson's disease cybrids
Mitochondrial dysfunction has been implicated in the dopaminergic neurodegeneration, which characterizes Parkinson’s disease (PD). The activities of mitochondrial complexes I and IV were found to be reduced in the brains of PD patients (n = 4) as compared to age-matched controls (n = 4). This is tested in SH-SY5Y cell lines, transformed Rho0 cells, and in normal and PD cybrid cell lines. Cybrid...
متن کاملFunction of mitochondrial complex-I and -IV in normal human and Parkinson's disease cybrids
Mitochondrial dysfunction has been implicated in the dopaminergic neurodegeneration, which characterizes Parkinson’s disease (PD). The activities of mitochondrial complexes I and IV were found to be reduced in the brains of PD patients (n = 4) as compared to age-matched controls (n = 4). This is tested in SH-SY5Y cell lines, transformed Rho0 cells, and in normal and PD cybrid cell lines. Cybrid...
متن کاملDynamics of cytochrome bf complex of photosynthesis apparatus
Photosynthesis is a process under which, the radiative energy is converted into the chemical one. Compared to the man-made devices, the photosynthesis apparatus is much more efficient. This high efficiency comes from its elaborate structure, very fast transition rates and a complex electron and proton transfer chain among the subunits of the apparatus. Its main subunits (Photosystem I (PSI), bf...
متن کاملDefinition of the nuclear encoded protein composition of bovine heart mitochondrial complex I. Identification of two new subunits.
Mitochondrial NADH:ubiquinone oxidoreductase (complex I) from bovine heart is a complicated multisubunit, membrane-bound assembly. Seven subunits are encoded by mitochondrial DNA, and the sequences of 36 nuclear encoded subunits have been described. The subunits of complex I and two subcomplexes (Ialpha and Ibeta) were resolved on one- and two-dimensional gels and by reverse-phase high performa...
متن کامل3D Gel Map of Arabidopsis Complex I
Complex I has a unique structure in plants and includes extra subunits. Here, we present a novel study to define its protein constituents. Mitochondria were isolated from Arabidopsis thaliana cell cultures, leaves, and roots. Subunits of complex I were resolved by 3D blue-native (BN)/SDS/SDS-PAGE and identified by mass spectrometry. Overall, 55 distinct proteins were found, seven of which occur...
متن کامل